| Accession | PRJCA000268 | ||||||||||
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| Title | Mechanism of multi-gene interactions underlying the genetic adaptation to high altitude hypoxia in Tibetan populations | ||||||||||
| Relevance | Evolution | ||||||||||
| Umbrella project |
eGPS: evolutionary Genotype-Phenotype Systems biology Plateau Adaptability Study on genetic basis of environmental adaptation in Tibetan Plateau |
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| Data types | Transcriptome or Gene expression | ||||||||||
| Organisms | Mus musculus | ||||||||||
| Description | The Tibetan Plateau is the highest mountainous area in the world, an ideal "laboratory" for studying the molecular mechanism of how living organisms adapt to the environmental extreme of high altitude hypoxia. Tibetans, as the indigenous population living in the Tibetan Plateau region have been well-adapted to the high-altitude environment due to longtime natural selection, making them an ideal population for studying adaptation to high-altitude hypoxia in humans. This project aims to dissect the sequence variations and their functions of the 18 candidate genes, selected based on our previous genome-wide analyses in Tibetans, and they are likely involved in hypoxic adaptation. We intend to reveal the strength and timing of natural selection acting on these candidate genes in Tibetans. Combining the approaches of large-sample-size genetic association analysis, gene expression profiling of placenta tissue (an important oxygen-exchange organ), induced hypoxia experiment using endothelial cells and transgenic analysis, we sought to understand "how humans and other organisms have improved their physiological functions through interactions among multiple genes in the genome and developed the ability for high-altitude hypoxia adaptation". The results of this project will shed light on the molecular mechanism of adaptation to high-altitude hypoxia in humans, and will provide valuable genetic data for drug design in order to prevent and cure the high-altitude related diseases, which is crucial not only for basic research , but also for future medical applications. | ||||||||||
| Sample scope | Multispecies | ||||||||||
| Release date | 2016-11-04 | ||||||||||
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| Submitter | Yaoxi He (heyaoxi@mail.kiz.ac.cn) | ||||||||||
| Organization | Kunming Institute of Zoology, CAS | ||||||||||
| Submission date | 2016-09-07 |