Accession PRJCA000268
Title Mechanism of multi-gene interactions underlying the genetic adaptation to high altitude hypoxia in Tibetan populations
Umbrella project

eGPS: evolutionary Genotype-Phenotype Systems biology

Plateau Adaptability

Study on genetic basis of environmental adaptation in Tibetan Plateau

Data type Transcriptome or Gene expression
Organism Mus musculus
Description The Tibetan Plateau is the highest mountainous area in the world, an ideal "laboratory" for studying the molecular mechanism of how living organisms adapt to the environmental extreme of high altitude hypoxia. Tibetans, as the indigenous population living in the Tibetan Plateau region have been well-adapted to the high-altitude environment due to longtime natural selection, making them an ideal population for studying adaptation to high-altitude hypoxia in humans. This project aims to dissect the sequence variations and their functions of the 18 candidate genes, selected based on our previous genome-wide analyses in Tibetans, and they are likely involved in hypoxic adaptation. We intend to reveal the strength and timing of natural selection acting on these candidate genes in Tibetans. Combining the approaches of large-sample-size genetic association analysis, gene expression profiling of placenta tissue (an important oxygen-exchange organ), induced hypoxia experiment using endothelial cells and transgenic analysis, we sought to understand "how humans and other organisms have improved their physiological functions through interactions among multiple genes in the genome and developed the ability for high-altitude hypoxia adaptation". The results of this project will shed light on the molecular mechanism of adaptation to high-altitude hypoxia in humans, and will provide valuable genetic data for drug design in order to prevent and cure the high-altitude related diseases, which is crucial not only for basic research , but also for future medical applications.
Sample scope Multispecies
Release date 2016-11-04
PubMed ID Article title Journal name DOI Year
28096303 Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia. Molecular biology and evolution 10.1093/molbev/msw280 2017
Submitter Yaoxi    He  (
Organization Kunming Institute of Zoology, CAS
Submission date 2016-09-07

Project Data

Resource name Description
BioSample (100) -
SAMC007112 150521_spleen
SAMC007111 150521_lung
SAMC007110 150521_liver
SAMC007109 150521_kidney
SAMC007108 150521_heart
SAMC007107 150518_spleen
SAMC007106 150518_lung
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SAMC007101 150517_lung
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SAMC007090 150515_liver
SAMC007089 150515_kidney
SAMC007088 150515_heart
SAMC007087 150514_spleen
SAMC007086 150514_lung
SAMC007085 150514_liver
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SAMC007080 150513_liver
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SAMC007074 150512_kidney
SAMC007073 150512_heart
SAMC007072 150505_spleen
SAMC007071 150505_lung
SAMC007070 150505_liver
SAMC007069 150505_kidney
SAMC007068 150505_heart
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SAMC007066 150503_lung
SAMC007065 150503_liver
SAMC007064 150503_kidney
SAMC007063 150503_heart
SAMC007062 141123_spleen
SAMC007061 141123_lung
SAMC007060 141123_liver
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SAMC007058 141123_heart
SAMC007057 141122_spleen
SAMC007056 141122_lung
SAMC007055 141122_liver
SAMC007054 141122_kidney
SAMC007053 141122_heart
SAMC007052 141120_spleen
SAMC007051 141120_lung
SAMC007050 141120_liver
SAMC007049 141120_kidney
SAMC007048 141120_heart
SAMC007047 141119_spleen
SAMC007046 141119_lung
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SAMC007044 141119_kidney
SAMC007043 141119_heart
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SAMC007036 141117_lung
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SAMC007032 141115_spleen
SAMC007031 141115_lung
SAMC007030 141115_liver
SAMC007029 141115_kidney
SAMC007028 141115_heart
SAMC007027 141113_spleen
SAMC007026 141113_lung
SAMC007025 141113_liver
SAMC007024 141113_kidney
SAMC007023 141113_heart
SAMC007022 141112_spleen
SAMC007021 141112_lung
SAMC007020 141112_liver
SAMC007019 141112_kidney
SAMC007018 141112_heart
SAMC007017 141111_spleen
SAMC007016 141111_lung
SAMC007015 141111_liver
SAMC007014 141111_kidney
SAMC007013 141111_heart
GSA (1) -
CRA000129 CRA_129