Introduction

The genes encoding many biomolecular systems and pathways are genomically organized in operons or gene clusters. With MultiGeneBlast, we provide a user-friendly and effective tool to perform homology searches with operons or gene clusters as basic units, instead of single genes. The contextualization offered by MultiGeneBlast allows users to get a better understanding of the function, evolutionary history, and practical applications of such genomic regions. The tool is fully equipped with applications to generate search databases from GenBank or from the user's own sequence data. Finally, an architecture search mode allows searching for gene clusters with novel configurations, by detecting genomic regions with any user-specified combination of genes. Sources, precompiled binaries, and a graphical tutorial of MultiGeneBlast are freely available from http://multigeneblast.sourceforge.net/.

Publications

  1. Detecting sequence homology at the gene cluster level with MultiGeneBlast.
    Cite this
    Medema MH, Takano E, Breitling R, 2013-05-01 - Molecular biology and evolution

Credits

  1. Marnix H Medema
    Developer

  2. Eriko Takano
    Developer

  3. Rainer Breitling
    Investigator

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Summary
AccessionBT005689
Tool TypeApplication
Category
PlatformsLinux/Unix
Technologies
User InterfaceTerminal Command Line
Download Count0
Submitted ByRainer Breitling